Drug Standards
Cayman Chemical R-FlurbIprofen 500mg
A COX-inactive enantiomer of flurbiprofen; inhibits γ-secretase activity in vitro; reduces formation of Aβ42 and improves axonal transport in young Aβ-plaque free mice in the Tg2576 transgenic model of Alzheimer's disease; inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages; reduces paw edema in a rat model of zymosan-induced inflammation at 1, 3, and 9 mg/kg; suppresses prostate tumor cell growth in vitro and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia
Cayman Chemical Mifepristone Neurochemicals
An antagonist of glucocorticoid, progesterone, and androgen receptors (Kis = 0.1, 0.64, and 0.65 nM, respectively); selective for these receptors over MR, ERα, and ERβ (Kis = 640, >200, and >750 nM, respectively); inhibits R5020-stimulated alkaline phosphatase activity as well as reporter transcription stimulated by either dexamethasone or R5020 in cell-based assays (IC50s = 7, 5.9, and 1.3 nM, respectively); inhibits R1881-stimulated reporter transcription in a concentration-dependent manner; inhibits growth of 4-OHT-resistant MCF-7 breast cancer cells in vitro at 10 µM; inhibits tumor growth in an SKOV3 ovarian cancer nude mouse xenograft model at 0.5 or 1 mg per day
Sigma Aldrich Fine Chemicals Biosciences Frovatriptan Related Compound A United States Pharmacopeia (USP) Reference Standard | 147008-88-6 | 20MG
Frovatriptan Related Compound A United States Pharmacopeia (USP) Reference Standard | Mol Wt: 229.28 | 147008-88-6 | 20MG
Apexbio Technology LLC Desogestrel 54024-22-5 25mg
Desogestrel (CAS 54024-22-5) is a synthetic progestogen derivative targeting the progesterone receptor It is designed to selectively activate this receptor thereby suppressing gonadotropin secretion and inhibiting ovarian follicle maturation and ovulation Desogestrel exerts its biological activity primarily through selective activation of progesterone receptors Based on its chemical structure desogestrel contains an alkyne functional group that enables participation in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with azide-containing molecules Based on these pharmacological properties desogestrel holds research potential in targeted drug modification probe labeling and pharmacological investigations as well as serving as an active ingredient in oral contraceptive formulations
Sigma Aldrich Fine Chemicals Biosciences Methacrylic acid copolymer type B United States Pharmacopeia (USP) Reference Standard | 25086-15-1 | MFCD00243185 | 200MG
Methacrylic acid copolymer type B United States Pharmacopeia (USP) Reference Standard | 25086-15-1 | MFCD00243185 | 200MG
Sigma Aldrich Fine Chemicals Biosciences Diclofenac Compoun100MG
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Medchemexpress LLC Gitoxin | 4562-36-1 | MFCD00021173 | 95.0% | 780.94 | C41H64O14 | 5 MG
Gitoxin is a cardenolide (cardiac) glycoside that inhibits the Na+/K+-ATPase. Used as an analytical standard and research reagent, it commonly appears as a metabolic degradation product of digitoxin and is supplied in small milligram quantities suitable for chromatographic, mass spectrometry, and biochemical assays.
Medchemexpress LLC O-(2-heptyl) dabigatran ethyl ester | 1610758-21-8 | MFCD03093370 | 10mg
Dabigatran impurity 4 is an impurity of Dabigatran (HY-10163)
Medchemexpress LLC Lenalidomide-5-Br | 1010100-26-1 | MFCD32263142 | 99.9% | 323.15 g/mol | C13H11BrN2O3 | 100 G
Lenalidomide-5-Br is a brominated analog of lenalidomide that acts as a cereblon (CRBN) E3 ligase ligand used to recruit CRBN in targeted protein degradation and PROTAC synthesis. It is supplied as a high-purity solid reagent for synthetic and chemical biology applications.
- Brominated lenalidomide analog suitable for CRBN recruitment.
- High purity solid for synthetic chemistry and PROTAC assembly.
- Molecular formula C13H11BrN2O3, molecular weight 323.15 g/mol.
- Available in laboratory-scale quantities, including 100 G packs.
- Documents available: data sheet, safety data sheet, and certificate of analysis.
Medchemexpress LLC 2-(1-acetyl-3-iodoindazol-6-yl)sulfanyl-N-methylbenzamide | 1639138-00-3 | 50mg
Axitinib impurity 7 is an impurity of Axitinib (HY-10065)
Medchemexpress LLC Etoricoxib impurity 26 | 1350206-14-2 | 10mg
Etoricoxib impurity 26 is an impurity of Etoricoxib (HY-15321)
Sigma Aldrich Fine Chemicals Biosciences Mexiletine impurity D European Pharmacopoeia (EP) Reference Standard | 26583-71-1 |
Mexiletine impurity D European Pharmacopoeia (EP) Reference Standard | Mol Wt: 179.26 | 26583-71-1 |
Cayman Chemical LenalIdomIde 500mg
A derivative of thalidomide; reduces TNF-α production in isolated human PBMCs and whole blood stimulated by LPS from S. minnesota (IC50s = 13 and 25 nM, respectively); has been used as a building block in the synthesis of PROTACs that induce the degradation of IKZF1 and IKZF3 in MM.1S cells; reduces vascularization and total microvascular length in a rat mesenteric window assay model at 250 mg/kg per day, p.o.
Medchemexpress LLC DOTAP methylsulfate 100mg
DOTAP methylsulfat is a cationic lipid reagent a cationic derivative of trimethylammonium linked to two 18-carbon fatty acid tails each with a single olefin group DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis respectively DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain releases DNA into the cytoplasm and exerts gene delivery function DOTAP methylsulfat can be widely used in research fields such as gene therapy cell transfection and non-viral vector design up [1] up [2]
Chemie Tek BINIMETINIB MEK162 50MG
ARRY-162 is a potent, orally bioavailable and non-ATP competitive inhibitor of MEK1/2 (IC50 = 12 nM ) and cellular pERK (IC50 = 11 nM), selective against a panel of other 220 kinases (has no activity at 10 uM). It shows ex vivo inhibition of cytokine production such as IL-1, TNF and IL-6. It is currently in clinical trials.